References
Pauletto M, Giantin M, Tolosi R, Bassan I, Barbarossa A, Zaghini A, et al. Curcumin mitigates AFB1-induced hepatic toxicity by triggering cattle antioxidant and anti-inflammatory pathways: a whole transcriptomic in vitro study. Antioxidants. 2020;9(11):1059.
Maneeboon T, Chuaysrinule C, Mahakarnchanakul W. Optimization and validation of dispersive liquid-liquid microextraction for simultaneous determination of Aflatoxins B1, B2, G1, and G2 in senna leaves and pods using HPLC-FLD with pre-column derivatization. Toxins. 2023;15(4):277.
Zhang M, Jiao P, Wang X, Sun Y, Liang G, Xie X, et al. Evaluation of growth performance, nitrogen balance and blood metabolites of mutton sheep fed an ammonia-treated Aflatoxin B1-contaminated diet. Toxins. 2022;14(5):361.
Aikore MOS, Ortega-Beltran A, Eruvbetine D, Atehnkeng J, Falade TDO, Cotty PJ, et al. Performance of broilers fed with maize colonized by either toxigenic or atoxigenic strains of aspergillus flavus with and without an aflatoxin-sequestering agent. Toxins. 2019;11(10):565.
Abdel-Daim MM, Abdeen A, Jalouli M, Abdelkader A, Megahed A, Alkahtane A, et al. Fucoidan supplementation modulates hepato-renal oxidative stress and DNA damage induced by aflatoxin B1 intoxication in rats. Sci Total Environ. 2021;768:144781.
Gao X, Xu J, Jiang L, Liu W, Hong H, Qian Y, et al. Morin alleviates aflatoxin B1-induced liver and kidney injury by inhibiting heterophil extracellular traps release, oxidative stress and inflammatory responses in chicks. Poultry Sci. 2021;100(12):101513.
Gao XN, Liu SH, Tan L, Ding CC, Fan WT, Gao ZS, et al. Estrogen receptor a regulates metabolic-associated fatty liver disease by targeting NLRP3-GSDMD axis-mediated hepatocyte pyroptosis. J Agric Food Chem. 2021;69(48):14544–56.
He J, Feng X, Liu YY, Wang YX, Ge CY, Liu S, et al. Graveoline attenuates D-GalN/LPS-induced acute liver injury via inhibition of JAK1/STAT3 signaling pathway. Biomed Pharmacother. 2024;177:117163.
Liu W, Yang Y, Pushparaj K, Balasubramanian B. Evaluation of hepatic detoxification effects of Enteromorpha prolifera polysaccharides against Aflatoxin B1 in broiler chickens. Antioxidants. 2022;11(9):1757.
Liu X, Zhang Z, Ruan J, Pan Y, Magupalli V G, Wu H, et al. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 2016; 535(7610): 153-+.
Chao XJ, Qian H, Wang SG, Fulte S, Ding WX. Autophagy and liver cancer. Clin Mol Hepatol. 2020;26(4):606–17.
Han TY, Wang LL, Jiang Y, Fei SS, Liu YD, Liu ZJ, et al. Hyperoside alleviates zearalenone-induced liver injury by regulating mitochondrial calcium overload mediated excessive autophagy. Phytomedicine. 2025;143:156880.
Lim H, Lim Y-M, Kim KH, Jeon YE, Park K, Kim J, et al. A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes. Nat Commun. 2018;9:1438.
Sang R, Ge BJ, Li HF, Zhou HY, Yan KX, Wang W, et al. Taraxasterol alleviates aflatoxin B1-induced liver damage in broiler chickens via regulation of oxidative stress, apoptosis and autophagy. Ecotox Environ Safe. 2023;251:114546.
Wang Y, Li JX, Wang SS, Pang YH, Liu PX, Xie BX, et al. The hepatitis B virus promotes the progression of non-alcoholic fatty liver disease through incomplete autophagy. Free Radic Biol Med. 2023;204:326–36.
Yu J, Pedroso IR. Mycotoxins in cereal-based products and their impacts on the health of humans, livestock animals and pets. Toxins (Basel). 2023;15(8):480.
Yan Y, Zhang XY, Chen HY, Huang WN, Jiang HN, Wang CL, et al. Isolation and Aflatoxin B1-degradation characteristics of a microbacterium proteolyticum B204 strain from bovine faeces. Toxins. 2022;14(8):525.
Jiang Y, Ogunade IM, Pech-Cervantes AA, Fan PX, Li X, Kim DH, et al. Effect of sequestering agents based on a Saccharomyces cerevisiae fermentation product and clay on the ruminal bacterial community of lactating dai cows challenged with dietary aflatoxin B1. J Dairy Sci. 2020;103(2):1431–47.
Liu J, Xu T, Zhu W, Mao S. High-grain feeding alters caecal bacterial microbiota composition and fermentation and results in caecal mucosal injury in goats. Br J Nutr. 2014;112(3):416–27.
Lin LX, Cao QQ, Zhang CD, Xu TT, Yue K, Li Q, et al. Aflatoxin B1 causes oxidative stress and apoptosis in sheep testes associated with disrupting rumen microbiota. Ecotoxicol Environ Saf. 2022;232:113225.
Schrenk D, Bignami M, Bodin L, Chipman JK, del Mazo J, Grasl-Kraupp B, et al. Risk assessment of aflatoxins in food. EFSA J. 2020;18(3):6040.
Ruan H, Huang Y, Yue B, Lv J, Zhang Y, Miao K, et al. Insights into the intestinal toxicity of foodborne mycotoxins through gut microbiota: A comprehensive review. Compr Rev Food Sci F. 2023;22(6):4758–85.
Kaur K, Al-Khazaleh AK, Bhuyan DJ, Li F, Li CG. A review of recent curcumin analogues and their antioxidant, anti-inflammatory, and anticancer activities. Antioxidants. 2024;13(9):1092.
Marcon H, Griss LG, Molosse VL, Cecere BGO, Alba DF, Leal KW, et al. Dietary supplementation with curcumin-loaded nanocapsules in lambs: Nanotechnology as a new tool for nutrition. Anim Nutr. 2021;7(2):521–9.
Lan ZW, Tan FB, He JL, Liu JY, Lu M, Hu ZP, et al. Curcumin-primed olfactory mucosa-derived mesenchymal stem cells mitigate cerebral ischemia/reperfusion injury-induced neuronal PANoptosis by modulating microglial polarization. Phytomedicine. 2024;129:155635.
Wang Y, Liu F, Zhou X, Liu M, Zang H, Liu X, et al. Alleviation of oral exposure to Aflatoxin B1-induced renal dysfunction, oxidative stress, and cell apoptosis in mice kidney by curcumin. Antioxidants. 2022;11(6):1082.
Cao QQ, Lin LX, Xu TT, Lu Y, Zhang CD, Yue K, et al. Aflatoxin B1 alters meat quality associated with oxidative stress, inflammation, and gut-microbiota in sheep. Ecotox Environ Safe. 2021;225:112754.
Wang QY, Li AK, Yu H, Wang CQ, Wang T, Zhang J. Evaluation of cross-talk and alleviate potential of cytotoxic factors induced by deoxynivalenol in IPEC-J2 cells interference with curcumin. Int J Mol Sci. 2024;25(13):6984.
Liu HY, He Y, Gao XL, Li T, Qiao BX, Tang LX, et al. Curcumin alleviates AFB1-induced nephrotoxicity in ducks: regulating mitochondrial oxidative stress, ferritinophagy, and ferroptosis. Mycotoxin Res. 2023;39(4):437–51.
Li C, Zhang JT, Li YJ, Zhao XH, Liang H, Li KR, et al. Glutamate supplementation improves growth performance, rumen fermentation, and serum metabolites in heat-stressed Hu sheep. Front Nutr. 2022;9:851386.
Guo YX, Hassan FU, Li MW, Xie HD, Peng LJ, Tang ZH, et al. Effect of sodium nitrate and cysteamine on in vitro ruminal fermentation, amino acid metabolism and microbiota in buffalo. Microorganisms. 2022;10(10):2038.
Fu YH, He YH, Xiang KH, Zhao CJ, He ZQ, Qiu M, et al. The role of rumen microbiota and its metabolites in subacute ruminal acidosis (SARA)-induced inflammatory diseases of ruminants. Microorganisms. 2022;10(8):1495.
Hartinger T, Grabher L, Pacífico C, Angelmayr B, Faas J, Zebeli Q. Short-term exposure to the mycotoxins zearalenone or fumonisins affects rumen fermentation and microbiota, and health variables in cattle. Food Chem Toxicol. 2022;162:112900.
Gao J, Cheng BB, Liu YF, Li MM, Zhao GY. Effects of red cabbage extract rich in anthocyanins on rumen fermentation, rumen bacterial community, nutrient digestion, and plasma indices in beef bulls. Animal. 2022;16(5):100510.
Belanche A, Arturo-Schaan M, Leboeuf L, Yáñez-Ruiz D, Martín-García I. Early life supplementation with a natural blend containing turmeric, thymol, and yeast cell wall components to optimize rumen anatomical and microbiological development and productivity in dairy goats. J Dairy Sci. 2023;106(7):4634–49.
Yu SQ, Li LX, Zhao HY, Zhang SY, Tu Y, Liu M, et al. Dietary citrus flavonoid extract improves lactational performance through modulating rumen microbiome and metabolites in dairy cows. Food Funct. 2023;14(1):94–111.
Zhao L, Zhang L, Xu ZJ, Liu XD, Chen LY, Dai JF, et al. Occurrence of Aflatoxin B1, deoxynivalenol and zearalenone in feeds in China during 2018–2020. J Anim Sci Biotechno. 2021;12(1):74.
Kaplina A, Kononova S, Zaikova E, Pervunina T, Petrova N, Sitkin S. Necrotizing enterocolitis: the role of hypoxia, gut microbiome, and microbial metabolites. Int J Mol Sci. 2023;24(3):2471.
Jandhyala SM, Talukdar R, Subramanyam C, Vuyyuru H, Sasikala M, Reddy DN. Role of the normal gut microbiota. World J Gastroenterol. 2015;21(29):8787–803.
Ahlawat S, Asha, Sharma K K. Gut-organ axis: a microbial outreach and networking. Lett Appl Microbiol. 2021; 72(6): 636–68.
Sharma G, Garg N, Hasan S, Shirodkar S. Prevotella: an insight into its characteristics and associated virulence factors. Microb Pathog. 2022;169:105673.
Zafar H, Saier MH Jr. Gut bacteroides species in health and disease. Gut Microbes. 2021;13(1):1–20.
Xiao X, Singh A, Giometto A, Brito IL. Segatella clades adopt distinct roles within a single individual’s gut. NPJ Biofilms Microbiomes. 2024;10(1):114.
Tao WL, Zhu WY, Nabi F, Li ZZ, Liu J. Penthorum chinense Pursh compound flavonoids supplementation alleviates Aflatoxin B1-induced liver injury via modulation of intestinal barrier and gut microbiota in broiler. Ecotoxicol Environ Saf. 2023;255:114805.
Peng Y, Tun HM. Meet the extended Segatella copri complex. Cell Host Microbe. 2023;31(11):1766–9.
Huang YM, Cao JL, Zhu MP, Wang ZW, Jin Z, Xiong ZF. Nontoxigenic Bacteroides fragilis : A double-edged sword. Microbiol Res. 2024;286:127796.
Lakes JE, Richards CI, Flythe MD. Inhibition of Bacteroidetes and Firmicutes by select phytochemicals. Anaerobe. 2020;61:102145.
Zhang SY, Zhao YH, Lalsiamthara J, Peng Y, Qi LL, Deng SL, et al. Current research progress on Prevotella intermedia and associated diseases. Crit Rev Microbiol. 2025;51(4):545–62.
Drzewiecka D. Significance and roles of Proteus spp. bacteria in natural environments. Microb Ecol. 2016;72(4):741–58.
Aljahdali NH, Sanad YM, Han J, Foley SL. Current knowledge and perspectives of potential impacts of Salmonella enterica on the profile of the gut microbiota. BMC Microbiol. 2020;20(1):353.
Xu PF, Dong SH, Luo XY, Wei B, Zhang C, Ji XY, et al. Humic acids alleviate aflatoxin B1-induced hepatic injury by reprogramming gut microbiota and absorbing toxin. Ecotox Environ Safe. 2023;259:115051.
Liu SP, Kang WL, Mao XR, Ge L, Du H, Li JY, et al. Melatonin mitigates aflatoxin B1-induced liver injury via modulation of gut microbiota/intestinal FXR/liver TLR4 signaling axis in mice. J Pineal Res. 2022;73(2):e12812.
Pan H, Hu T, He Y, Zhong GL, Wu SF, Jiang XX, et al. Curcumin attenuates aflatoxin B1-induced ileum injury in ducks by inhibiting NLRP3 inflammasome and regulating TLR4/NF-κB signaling pathway. Mycotoxin Res. 2024;40(2):255–68.
Vance JE. Phospholipid synthesis and transport in mammalian cells. Traffic. 2015;16(1):1–18.
Deleault NR, Piro JR, Walsh DJ, Wang F, Ma JY, Geoghegan JC, et al. Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids. P Natl Acad Sci USA. 2012;109(22):8546–51.
Arendt BM, Ma DW, Simons B, Noureldin SA, Therapondos G, Guindi M, et al. Nonalcoholic fatty liver disease is associated with lower hepatic and erythrocyte ratios of phosphatidylcholine to phosphatidylethanolamine. Appl Physiol Nutr Metab. 2013;38(3):334–40.
Zhou J, Tang L, Wang JS. Aflatoxin B1 induces gut-inflammation-associated fecal lipidome changes in F344 rats. Toxicol Sci. 2021;183(2):363–77.
Meeusen JW, Donato LJ, Bryant SC, Baudhuin LM, Berger PB, Jaffe AS. Plasma ceramides: a novel predictor of major adverse cardiovascular events after coronary angiography. Arterioscler Thromb Vasc. 2018;38(8):1933–9.
Fang ZJ, Pyne S, Pyne NJ. Ceramide and sphingosine 1-phosphate in adipose dysfunction. Prog Lipid Res. 2019;74:145–59.
Beckmann N, Becker KA. Ceramide and related molecules in viral infections. Int J Mol Sci. 2021;22(11):5676.
Wang ZS, Li XB, Wang TC, Liao GQ, Gu JY, Hou RY, et al. Lipidomic profiling study on neurobehavior toxicity in zebrafish treated with aflatoxin B1. Sci Total Environ. 2023;898:165553.
Doran AC, Yurdagul A, Tabas I. Efferocytosis in health and disease. Nat Rev Immunol. 2020;20(4):254–67.
Yurdagul A, Doran AC, Cai BS, Fredman G, Tabas IA. Mechanisms and consequences of defective efferocytosis in atherosclerosis. Front Cardiovasc Med. 2018;4:86.
Kawano M, Nagata S. Efferocytosis and autoimmune disease. Int Immunol. 2018;30(12):551–8.
Kasikara C, Doran AC, Cai B, Tabas I. The role of non-resolving inflammation in atherosclerosis. J Clin Invest. 2018;128(7):2713–23.
Tajbakhsh A, Rezaee M, Kovanen PT, Sahebkar A. Efferocytosis in atherosclerotic lesions: malfunctioning regulatory pathways and control mechanisms. Pharmacol Ther. 2018;188:12–25.
Paul B, Lewinska M, Andersen JB. Lipid alterations in chronic liver disease and liver cancer. JHEP Rep. 2022;4(6):100479.
Wang Y, Wang Q, Yang TW, Yin JM, Wei FL, Liu H, et al. Analysis of immune and inflammatory microenvironment characteristics of noncancer end-stage liver disease. J Interf Cytok Res. 2023;43(2):86–97.
Monteiro HF, Faciola AP. Ruminal acidosis, bacterial changes, and lipopolysaccharides. J Anim Sci. 2020;98(8):skaa248.
Khafipour E, Krause DO, Plaizier JC. A grain-based subacute ruminal acidosis challenge causes translocation of lipopolysaccharide and triggers inflammation. J Dairy Sci. 2009;92(3):1060–70.
Wang YJ, Liu FJ, Liu MR, Zhou X, Wang M, Cao KX, et al. Curcumin mitigates aflatoxin B1-induced liver injury via regulating the NLRP3 inflammasome and Nrf2 signaling pathway. Food Chem Toxicol. 2022;161:112823.
Li XT, Lv ZM, Chen J, Nepovimova E, Long M, Wu WD, et al. Bacillus amyloliquefaciens B10 can alleviate liver apoptosis and oxidative stress induced by aflatoxin B1. Food Chem Toxicol. 2021;151:112124.
Ferriero R, Nusco E, De Cegli R, Carissimo A, Manco G, Brunetti-Pierri N. Pyruvate dehydrogenase complex and lactate dehydrogenase are targets for therapy of acute liver failure. J Hepatol. 2018;69(2):325–35.
El-Agamy DS. Comparative effects of curcumin and resveratrol on aflatoxin B1-induced liver injury in rats. Arch Toxicol. 2010;84(5):389–96.
Wiest R, Rath HC. Bacterial translocation in the gut. Best Pract Res Clin Gastroenterol. 2003;17(3):397–425.
Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006;124(4):783–801.
Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nature Immunol. 2000;1(5):398–401.
Rassa JC, Meyers JL, Zhang YM, Kudaravalli R, Ross SR. Murine retroviruses activate B cells via interaction with toll-like receptor 4. Proc Natl Acad Sci U S A. 2002;99(4):2281–6.
Cohen P. The TLR and IL-1 signalling network at a glance. J Cell Sci. 2014;127(11):2383–90.
Rao ZP, Zhu YT, Yang P, Chen Z, Xia YQ, Qiao CQ, et al. Pyroptosis in inflammatory diseases and cancer. Theranostics. 2022;12(9):4310–29.
Pennisi M, Crupi R, Di Paola R, Ontario ML, Bella R, Calabrese EJ, et al. Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in alzheimer disease. J Neurosci Res. 2017;95(7):1360–72.
Cui Y, Wang Q, Zhang X, Yang X, Shi Y, Li Y, et al. Curcumin alleviates Aflatoxin B(1)-induced liver pyroptosis and fibrosis by regulating the JAK2/NLRP3 signaling pathway in ducks. Foods. 2023; 12(5).
Zhao YG, Wu JY, Wang XY, Jia H, Chen DN, Li JD. Prokineticins and their G protein-coupled receptors in health and disease. G Protein Signaling Pathways in Health and Disease. 2019;161:149–79.
Hendrawan VF, Agustina GC, Residiwati G, Amir MAM. The effect of administration of nano-curcumin on the level of vascular endothelial growth factor (VEGF) expression and fetus length in pregnancy of mice under stress conditions. Int J Vet Sci. 2024;13(6):903–7.
Shen P, Huang KJ, Zhang XL, Yin GY, Qin MT, Ma H, et al. Genetically engineered MSC-derived hybrid cellular vesicles for ROS-scavenging and mitochondrial homeostasis in hepatic ischemia-reperfusion injury. Materials Today Bio. 2025;34:102215.
Guo R, Wang H, Cui N. Autophagy regulation on pyroptosis: mechanism and medical implication in sepsis. Mediat Inflamm. 2021;2021:9925059.
Dikic I, Elazar Z. Mechanism and medical implications of mammalian autophagy. Nat Rev Mol Cell Biol. 2018;19(6):349–64.
Liu S, Yao S, Yang H, Liu S, Wang Y. Autophagy: regulator of cell death. Cell Death Dis. 2023;14(10):648.
Li MY, Zhu XL, Zhao BX, Shi L, Wang W, Hu W, et al. Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS-AMPK-mTOR axis. Cell Death Dis. 2019;10:489.
Sun Q, Fan J, Billiar TR, Scott MJ. Inflammasome and autophagy regulation - a two-way street. Mol Med. 2017;23:188–95.
Wang XY, Li HQ, Li W, Xie J, Wang FJ, Peng XW, et al. The role of Caspase-1/GSDMD-mediated pyroptosis in Taxol-induced cell death and a Taxol-resistant phenotype in nasopharyngeal carcinoma regulated by autophagy. Cell Biol Toxicol. 2020;36(5):437–57.
